Current Management Recommendations for Prenatally Diagnosed Congenital Diaphragmatic Hernia
Posted by Surgery on Oct 9, 2008
After a patient is identified as carrying a fetus with a CDH, a comprehensive evaluation (:LASIX) should be undertaken to render proper family counseling. Both advanced-level ultrasonography and fetal echocardiography should be performed to screen for associated anomalies. A genetic screen and chromosomal analysis should also be performed. Being armed with this information, which includes particular specific determination of the LHR and liver herniation status, allows fetuses to be stratified according to expected outcome. In addition, those fetuses whose CDH is diagnosed before 24 weeks’ gestation have a poorer prognosis compared with those diagnosed later. If the issues regarding TO for CDH outlined previously can be resolved satisfactorily, then perhaps therapy for liver up, LHR less than 0.9 fetuses will once again be offered. It is yet to be determined if the promise of the theoretical therapeutic benefit of fetal intervention for CDH will be realized (45:LASIX).Based on the combined experience, an algorithm for the management of a fetus with a thoracic mass has been proposed (:LASIX) (14,15:LASIX). As with all cases considered for fetal intervention a comprehensive evaluation by US is undertaken in order to confirm the diagnosis, exclude concomitant anomalies and to determine the well-being of the fetus with regard to hydrops (Tables 3-4 and 3-5:LASIX). Nonhydropic fetuses are monitored by serial US surveillance based on recommendations derived from the CVR data. In addition, a genetic screen and chromosomal analysis by amniocentesis or PUBS and echocardiography are performed. If another life-threatening anomaly is discovered or the maternal mirror syndrome has developed, patients are excluded from further consideration for fetal surgery and are counseled. If a fetus with hydrops is identified or hydrops develops during the course of serial ultrasonographic surveillance, then management recommendations depend on gestational age. If a fetus with both a lung mass and hydrops is discovered at 32 weeks’ gestation or greater, early delivery and postnatal care is offered. Despite prompt perinatal resection, the outcome for the hydropic fetus and subsequent newborn has been dismal. In cases where a hydropic fetus with a chest mass is identified prior to 32 weeks’ gestation, then open fetal surgery for resection is offered. The role of steroids in this clinical setting as an alternative to fetal surgery needs to be examined. Fetuses without hydrops and those with shrinking tumors should be managed by planned delivery, maternal transport, and ex utero resection.



Greetings, I the practising surgeon from Serbia. Call me Ivan Govak. In the works I use works
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