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MITOCHONDRIA: Rythmol SR

Posted by Surgery on Jul 20, 2008

: SITE OF ENERGY TRANSDUCTION

The majority of cellular processes require the transduction of a large amount of energy. Hydrolysis of ATP is the most common reaction coupled to processes that require energy for completion. The mitochondrion is the major source of ATP synthesis for the cell. ATP is generated from ADP as the result of the oxygen consumption. This process is known as oxidative phosphorylation. In fact, the use about 80% of the oxygen taken up by the cells. are composed of two membranes, the outer membrane and the inner membrane, which are separated by the intermembrane space.

The outer membrane separates the organelle from the cytosol and contains channels that allow the passage of molecules with sizes lower than 5,000 Da. The inner membrane is folded forming a crest (cristae: ) containing the electron-transport chain. The central space of (matrix) contains mitochondrial nucleic acids and many enzymes, including those that participate in the Krebs cycle and in the fatty acid breakdown (as acetyl coenzyme A: ). In addition, several antioxidant enzymes, such as manganese superoxide dismutase, are present in the matrix. Some mitochondrial proteins (e.g., cytochrome C: ) are synthesized within this organelle. These proteins, as well as RNAs (e.g., ribosomal, messenger, transfer), are encoded by a circular double DNA molecule within the . Other protein constituents of the are synthesized in the cytosol and transported to this organelle. These polypeptides contain a peptide signal to target them to the . They are translocated across the membrane with the help of molecular chaperones (Hsc70 and Hsp90: ) that interact with TOM receptors on the organelle membrane.

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